Transgenic mice with 222K goat PRP show high resistance to BSE and scrapie.

Written by Jan Langeveld. Posted in Papers

In their paper “Role of the Goat K222-PrPC Polymorphic Variant in Prion Infection Resistance” Aguilar-Calvo and others show that transgenic mice expressing the wildtype (222Q) PRNP allele were fully susceptible to infection with all tested TSE isolates, whereas transgenic mice expressing similar levels of the 222K allele were resistant to all goat scrapie and cattle BSE isolates. However, these 222K mice are not resistant to goat derived BSE. However, the occurrence of goat BSE would be a very improbable condition. All the results presented support the view that the K222 polymorphic variant is a good candidate for selective breeding programs to control and eradicate scrapie in goat herds.