Written by Jan Langeveld. Posted in frontpage

grinThis website is dedicated to support eradication of goat TSEs!
It informs goat holders and producers, researchers, policy makers and public about our EU-supported project GOAT-TSE-FREE that started in Sept 2012 within the EMIDA ERA-NET framework and originated from the EU FP6 GoatBSE project. It brings you information on the current state-of-the-art as well as the next steps required to eradicate goat scrapie. The GoatBSE project provided a great fundament to understand goat TSE dynamics while the follow-ups take it to the next (practical) level. We provide information about plans and progress to enhance the goat scrapie resistance level in the project participating countries, which are: Italy, France, Germany, Greece, Netherlands, Spain and United Kingdom. Cyprus is involved as a contributing partner.

Frequencies of PrP codons 222K, 146S and 146D contributing to resistance to classical scrapie.

Written by Jan Langeveld. Posted in frontpage

In several countries (Italy incl. Sicily and Sardinia, Greece, United Kingdom, France, Spain, Germany) have been performed more extended searches for existence of live PrP resistance polymorphism carriers under goats. The PrP-alleles of interest were especially Q222K, N146D and N146S, shortly indicated as 222K, 146S and 146D. 

Transgenic mice with 222K goat PRP show high resistance to BSE and scrapie.

Written by Jan Langeveld. Posted in frontpage

In their paper “Role of the Goat K222-PrPC Polymorphic Variant in Prion Infection Resistance” Aguilar-Calvo and others show that transgenic mice expressing the wildtype (222Q) PRNP allele were fully susceptible to infection with all tested TSE isolates, whereas transgenic mice expressing similar levels of the 222K allele were resistant to all goat scrapie and cattle BSE isolates. However, these 222K mice are not resistant to goat derived BSE. However, the occurrence of goat BSE would be a very improbable condition. All the results presented support the view that the K222 polymorphic variant is a good candidate for selective breeding programs to control and eradicate scrapie in goat herds.

Genetic resistance to scrapie from France and Italy

Written by Jan Langeveld. Posted in frontpage

With the study of Lacroux et al., 2013, there are now two experimental studies that show the high level of scrapie resistance contributed by the 222K allele in goats. These experimental challenge studies in goats confirm the findings in the field that the 222K allele confers a high level of unsusceptibility to scrapie in goats, supporting its usefulness for breeding programs.

October 2013, goat TSE information: new and old.

Written by administrator. Posted in frontpage

Check the tabs: NEWS brings short stories of our work and experiences in the field, PROJECT contains documents concerning project structure and plans, PUBLICATIONS contains articles from and in relation to the project, posters and presentations, PARTNERS exhibits as much as possible people involved in it. CONTACTS, you may wish to contact us about issues, then you just write the administrator and even a call is welcome.

GoatBSE has information about how the research from 2003-2012 that showed the way to choose for the 222K allele as a reliable target for goat breeding towards scrapie resistance.

At the right column under National Work Documents you find basic information, that directly concerns the goat holders and policy makers about involving goat sector in participating countries to generate a reservoir of scrapie resistance allele carriers while recording production trait information. Click on the flags for your country (if it is participating/contributing).